Little was born in Cape Town, South Africa. She was the low individual at the 1971 World Amateur Team Championship and won the South African Match Play and Stroke Play titles that same year. As an amateur, she tied for fifth at the 1971 Lady Carling Open.
Little joined the LPGA Tour in 1971 and was named LPGA Rookie of the Year. Her first professional win was at the 1976 Women’s International and it came in dramatic fashion. Little holed a shot from a greenside bunker on the 72nd hole to edge Jan Stephenson by one shot.
Little’s best season was 1982, when she finished third on the money list. She has won 15 times on the tour, including two major championships, the 1988 du Maurier Classic and the 1980 LPGA Championship. She was awarded the 1989 Ben Hogan Award from the Golf Writers Association of America and was recognized during the LPGA’s 50th Anniversary in 2000 as one of the LPGA’s top-50 players and teachers.